AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |
Back to Blog
Rawtherapee subfolder3/17/2023 ![]() There still is filtering by camera, lens, ISO, mm and all that good stuff. My photos are sorted by Year then a sub-folder for events in that year, I'd recommend using the Film Roll mode in collected images as the Folders view shows everything in that year recursively from every sub folder, I've yet to find a setting to show only the selected folder but filmroll works in that way to start with. Next up, how do you sort your photos? Well I hope it's by folders as that's how Darktable really likes to do it.Īlright, thats just the way I like to do it Also with time you'll have a chance to refine your skills with the new software. This part can be a major pain in the ass but if you're doing new jobs at a relative pace then you'll have new material to work with all the time rather than having time to worry about old ones. Just make sure to not apply the watermark to it just in case you want to print it out later for selling/show/hanging-on-the-wall. But if you have way to many photos or don't want to loose what you have so far then go ahead and export your edited photos at full resolution. I found it good practice to go back with Darktable and redo choice old photos I've already exported out of Lightroom with all the touch ups and get it as close as possible. Next check your library for converted panoramic and HDR renders from either Lightroom or Photoshop, they will most likely be DNG or PSD, you'll need to convert that over to something universal like a TIFF file as for me Darktable would tell me the DNG file generated from panoramics was unreadable.Īs for your Lightroom library itself, you won't be able to keep it going forward. While DNG is technically an 'open' file format it's still non-free and fairly proprietary to adobe ( it's just a fancy TIFF anyway), so I hope you saved your originals. If you've converted your entire library to DNG, then go and grab the original camera raws. Luminance HDR - A fully automated HDR program.īefore dropping Adobe all together make sure you prep your library. Hugin Panorama Photo Stitcher - This is what you'll be using to make panoramic shots. Keep in mind however you'll need to get G'MIC addon and possibly a few others to really fill it out in making it feature complete. GIMP - This is really the most straight forward alternative to Photoshop you can get. I know other photographers really go all in with editing some of their photos which I'm confident is still possible. Though I'd recommend grabbing an updated version from one of the following sources: Appimage, Flatpak, Snap package or PPA source if you're Ubuntu based.įor me personally I did everything in Lightroom, the few things Photoshop was used for was panoramics and HDR shots. Most of these programs should be available in your package manager of choice if you're running Linux. Shotwell - If you need something simple and to the point for just cropping/rotate and adjusting exposure then Shotwell works nicely. Rawstudio - haven't used this one but looks to be a straight forward RAW editor. It's what I use to navigate through my collection of reference pictures for doing art, kinda-sorta along the lines of Adobe Bridge. Rawtherapee - Also a powerful tool much like Darktable/Lightroom.ĭigiKam - digiKam is a raw photo editor but I find it to be more useful as a photo library browser and metadata editor for large groups of pictures. At the time of writing this up they now have builds for just about any OS of your choice! Windows builds are fairly new at the time of writing this up. As I personally only used Darktable that is what I'll be covering, but do know there are other choices!Īs for choices there is quite a few, just keep in mind that some of these might only be for Linux distributions and might not have a Windows or macOS release.ĭarktable - What I'll be mainly covering. There are quite a few choices and even more if you want simpler tools, but if you're being paid for your work then something more substantial will be required. There are things I wish I knew about switching away from Adobe stuff so I hope the following helps out in preparing your photos/files for the big switch over. If you've used a tool chain of Lightroom and Photoshop together then things are going to get more complicated but very do able once you've dedicated yourself to going all the way. This is a collection of information I wish I knew when switching to alternative software. Keep backups of your original RAW photos along with library/catalogs or whatever database you and your software created. What works for me might not work for you. The following is my opinion and personal use case about lots of different software for photography.
0 Comments
Read More
Back to Blog
Mbox splitter online3/17/2023 ![]() ![]() Click on View button to open mbox file 4. Wait until upload and processing is complete 3. Click inside drop area, drag & drop or paste URL to mbox file 2. ![]() Then, delete all the messages above that Message ID and save it. GET STARTED WITH ONLINE mbox VIEWER Open mbox documents in the document viewer Get Started FREE HOW-TO view mbox 1.Step 1 : Launch BitRecover MBOX File Splitter Wizard. Find the unique Message ID from where you split MBOX file. Follow these steps to split MBOX files into various smaller parts. Delete entire message below that point and save the file. Note: You can copy that ID separately to notepad or notes for reference. MacUncle MBOX Splitter Standard License Pro License. It contains a unique value for every mail. Purchase MacUncle MBOX Splitter Full Version and Bundle Offer. Search for the header named as Message ID. It has Select File or Add Folder options to choose MBOX file from computer or storage devices like pen drives and hard drives so users can choose email files easily. Click anywhere in the middle of the file. MBOX file splitter is designed in such a way that it is able to split single and multiple MBOX files into small MBOX files.Open one of those copies with the text editor.Create two extra copies of the mbox file.Now, in option as an In-App Purchase, the user has an option to view and export the resulting messages. Once you have installed the text editor of your choice, follow the given order of steps: Mbox Splitter is an application that can split a standard Unix mbox file or a mbox package export by Apple Mail using the 'Export Mailbox' feature, into single messages in eml format. Make sure you check the platform compatibility to run these editors on your system. Download Mbox Splitter for macOS 10.9 or later and enjoy it on your Mac. You can use any text editor including Notepad++, JujuEdit, EditPad Pro, EditPad Lite, EmEditor, HiEditor, HxD, ifhex, HexFiend, UltraEdit, VEDIT, VEDIT Pro64, and Vim for this. Read reviews, compare customer ratings, see screenshots, and learn more about Mbox Splitter. Splitting your MBOX files using a text editor could be a great way to reduce mailbox size.
Back to Blog
Crackerbox doodle war game3/17/2023 ![]() We're pleased that we were able to allude to various stories from Hokkaido in the north to Okinawa in the south in the Doodle. Lucky the Ninja Cat, who is both cool and cute, is definitely a favorite aspect! What’s your team’s favorite aspect of the Doodle? ![]() Each character’s design was based on their original story image, but then adapted for the game. The team mascots and the characters in the city such as Kappa, Yatagarasu, lion dance, were also chosen as they are very well known across Japan. In the design process, each event champion was selected from those unique stories. ![]() Next, we connected those folktales and characters with each of the sport events included in the game. Can you tell us about your creative process for adapting each of the characters in the Doodle? Below they share their thoughts behind the making of this Doodle: The cutscene animations and characters for Doodle Champion Island Games were created by Tokyo, Japan-based animation studio, STUDIO4☌. Outsprint these spry tree spirits, and don’t let the crazy crustaceans slow you down Scale to the mountain top, but avoid the obstacles from this ladle-yielding owl champion Sea if your rhythm is unWAVEring when you visit this champion’s underwater kingdom Sur-purrr-ise Supporting Lineup | Momotaro & friends Show your gnarliest aerial moves to beat this shapeshifting tricksterĪim quickly and accurately to outscore this Samurai general and expert marksmanĭart, dip, and dodge these fearsome foes to reach your goal T ake a shot at table tennis against this mischievous bird of prey Your Fur-midable Opponents: The Legendary Champions Go behind-the-scenes of today’s interactive Doodle, made in partnership with Tokyo-based animation studio, STUDIO 4☌!Ĭome back tomorrow to keep up with Lucky, check the real-time team leaderboard standings, and watch the action unfold in the Doodle Champion Island Games!Ĭompete in the Champion Island Games as Lucky-your new favorite feline. Her ultimate goal? Defeat each sport Champion to collect all seven sacred scrolls-and complete extra hidden challenges across Champion Island in the purrr-ocess.Īre you feline Lucky □ ? Click on today’s Doodle, join one of the four color teams to contribute to the real-time global leaderboard, and let the games begin! contexts into what Edward Said called a contrapuntal harmony.Welcome to the Doodle Champion Island Games! Over the coming weeks, join calico (c)athlete Lucky as she explores Doodle Champion Island: a world filled with seven sport mini-games, legendary opponents, dozens of daring side quests, and a few new (and old )) friends. This new paradigm aims to capture the culturally specific ideological work of American humor and to braid the diverse themes, stock characters and plots, media, rhetorical conventions, and techniques that have been shaped by colonial, postcolonial, and neocolonial relations in U.S. hegemony across the land and people of North America (and beyond). Three seem immediately important: colonial continuity with comic traditions drawn from those of previous European imperial powers in the Americas, postcolonial discontinuity in comic traditions (such as vernacular humor) marked by anti-imperialist and anti-aristocratic ideologies grounded in the American Revolution, and neocolonial hybridization of native, immigrant, and other national or ethnic comic traditions through U.S. Judith Yaross Lee invites other scholars to join her at the 2020 Quarry Farm Symposium on the topic-and in their own research on stand-up comedy and literary, film, television, and graphic humor-in order to probe how the unequal transnational political relationships of imperialism have shaped the basic components (plot, character, incident), rhetorical conventions, and comic techniques-the constituent matters of empire-underlying comic traditions in the United States. This article draws on a broad range of examples to outline how imperialism can serve as a key concept for the cultural analysis of American humor across varied themes, media, genres, historical eras, and identity standpoints.
Back to Blog
Autororrection for typinator spanish3/17/2023 ![]() The price still starts at $1299, and it remains limited to 8 GB of RAM and a single USB-C port. A new rose gold finish joins the existing gold, silver, and space gray color options. Over a year after its introduction (see “ New 12-inch MacBook Joins Updated MacBook Air and MacBook Pro,” 9 March 2015), Apple has updated the 12-inch MacBook with new Intel Skylake processors, better graphics performance, faster flash storage, and an extra hour of battery life. ![]() Josh CentersĪpple Updates 12-inch MacBook, Bumps MacBook Air RAM And WWDC is far from the only Apple conference being held in 2016, or even the only Apple conference being held in San Francisco that week - see “ 31 Conferences for Mac and iOS Professionals in 2016” (6 January 2016) for information on the wide world of Apple-focused events. Students and participating STEM organizations still have a chance to attend, as registration for WWDC scholarships remains open until at 5:00 PM PDT.Įven if you can’t make the trip - or didn’t get a ticket in the lottery - you’ll still be able to stream the keynote and many of the sessions. Unfortunately, WWDC registration is now closed, but if you entered the lottery, you should soon have notice in your email inbox informing you of whether you secured a ticket or not. To have scored a WWDC golden ticket in Apple’s lottery will also be able to have one-on-one consultations with Apple experts, and enjoy a bash on June 16th with music, food, and drink. However, the more than 100 technical sessions and labs will be held at Moscone West. Interestingly, the much-anticipated keynote won’t be held in the Moscone West conference center, but instead at the nearby Bill Graham Civic Auditorium, which has more seats than the main auditorium at Moscone West. WWDC remains the premiere annual event for Apple developers, and we expect to learn about the next versions of OS X (rumored to be redubbed MacOS), iOS, watchOS, and tvOS during its opening keynote address. #1641: LastPass breached, Live Text aids recipe input, fix for failed MobileDeviceUpdater installsĪpple has announced dates for the 2016 installment of its Worldwide Developers Conference (WWDC), which will be held from June 13th through 17th in San Francisco.#1642: How to identify phishing attacks, new iPhone and iPad passcode requirements.#1643: New Mac mini and MacBook Pro models, new second-gen HomePod, security-focused OS updates, industry layoffs.#1644: Explaining Mastodon and the Fediverse, HomePod Software 16.3 and tvOS 16.3, GoTo breach.#1645: AirPlay iPhone to Mac for remote video, Siri learns to restart iPhones, Apple's Q1 2023 financials.Typinator requires Mac OS X 10.4 (Tiger) or later, but Leopard is recommended.ĭownload Typinator 3. Issues that were in need of being resolved included a problem that caused the memory requirements of Typinator to grow after certain editing operations, an issue where Typinator refused to import sets from certain locations near the Application Support folder, and a fault with the conversion of large expansions from older set formats.Īccording to Ergonis, Typinator 3.3 also works around a problem in NetBeans that has been causing the application to insert the previous contents of the clipboard. Typinator updates its preferences file less often under heavy use.Option to count replacements as corrections or expansions.Smarter handling of apostrophes covers most special cases in English and French.The whole word and case options can now be changed for multiple abbreviations in one step.Two new built-in sets with Unicode subscript and superscript characters.Typinator now uses separate default sounds for expansions and corrections.The rest of the changes can be found in the highlights list just below. ![]() Additionally, the new version includes increased compatibility with Adobe Acrobat. It helps users quickly insert phrases or pictures into any type of document, and eliminates errors by automating the process of inserting frequently used text and graphics and auto-correcting typing errors, thus boosting productivity.Įrgonis reveals that Typinator 3.3 now allows users to define set-specific options, where they can specify common prefix and suffix characters for all abbreviations within a set, define separate expansion sounds and add notes per set. Typinator is a very useful tool for auto-typing text and auto-correcting typos across all Mac OS X applications that use text and / or images. Several bug fixes are also listed in the changelog for Typinator 3.3. The new release adds predefined sets with subscript and superscript characters and separate auto-correction dictionaries for US and British English, among other enhancements. Ergonis Software has released version 3.3 of its auto-typing and auto-correcting utility, Typinator.
Back to Blog
Planet coaster vs parkitect3/17/2023 ![]() Simply create a Roller Coaster with the editor provided, save it, and then test it out. There is no theme park management in Aircoaster. NoLimits 2 Roller Coaster Simulation (PC)Īircoaster is the most realistic Roller Coaster build and ride simulation game available for Apple devices. RollerCoaster Tycoon 2: Triple Thrill Pack (PC) RollerCoaster Tycoon Classic (Android, IOS, PC) Thrillville: Off The Rails (PC, Xbox 360) RollerCoaster Tycoon Touch & 4 Mobile (Android, IOS) – Our very first “Systems Scan” – Click the link to find out more about what the series intends to do! As always, we welcome feedback.ĭeveloped by Texel Raptor, Parkitect came out November 29th, 2018 to decent critical acclaim. Many of the Steam Reviews lauded it as the “proper return of Roller Coaster Tycoon“, an excellent theme park building game of yesteryear.įor those unfamiliar with this game, Parkitect puts you in the shoes of a theme park manager, giving you the reins to build the next Busch Gardens all by yourself. Of course, that means that you’ll need to work within a budget and keep the rides, the staff, and other amenities’ costs in mind as you expand your park. You’ll research various rides of the coaster and non-coaster variety as you progress through a series of scenarios, or you can free play to your heart’s content in the sandbox mode. The coaster-builder system allows you to build your own track design from scratch, or you can use any of the many pre-fab designs. Better yet, you can also import designs from the Steam Workshop, along with many other user creations. The integration here is seamless.Ĭustomer satisfaction will measure your park’s success, which you can easily keep an eye on through an easy-to-understand satisfaction breakdown. You can also effortlessly identify which rides are giving your patrons the most thrills, too. The people love the log flume? Okay, I’ll make another bigger and better one! That will help guide you in your ride addition thought process. ![]() ![]() You’ll also need to consider resource routes so that the hamburger and hotdog stands are well supplied and that the demand for them is well met.Īll of these game mechanics are brought together by an easy-to-understand user interface and superb graphics that are reminiscent of earlier tycoon games but are distinctly their own. They still feel modern, however, just with a retro twist. Speaking of the UI, Parkitect has all the switches and toggles that any grognard would want. Want to know how pretty your park is or…is not? There’s a quick way to see where the trouble spots might be. Your park-goers tend to dislike looking at trash cans and toilets, so you’ll probably be figuring out ways to hide them as best you can. Do you want your G-Forces overlay? Well, you’ve got your G-Forces overlay! Conclusionĭespite how boring or micro-intensive managing the staff and budget or laying out supply routes may sound to some of you, Parkitect does a fantastic job of making it simple enough to manage for those more interested in focusing on the roller coasters and ride building. Taste of Adventure is a great addition to a great game For those that enjoy that aspect, too, it’s deep enough and detailed enough to fill your needs, as well. Parkitect is the Roller Coaster Tycoon that I’ve wanted since the early ’00s and then some. The user interface is superb, the presentation is charming and whimsical, and the rides are varied and fun. #Planet coaster vs parkitect Patchįurthermore, a recent expansion, called “ Taste of Adventure“, has added an incredible amount of content, with many more rides, features, and themes, while the V 1.5 patch brought on a host of new free features, too. Simply put, if you enjoyed Roller Coaster Tycoon or even the more recent Planet Coaster, you’d be an utterly daft, moronic simpleton if you didn’t add this to your gaming roster. You’ve wanted a modern Roller Coaster Tycoon, but still wanted a retro aesthetic.You love planning out theme parks and don’t mind a little of the more mundane aspects, i.e.
Back to Blog
Chopin nocturn e minor3/17/2023 ![]() 10 and op.25, plus a further set of three without opus numbers), are widely considered to be amongst the pinnacles of the piano repertoire. His compositions, which are almost exclusively for the piano, such as the Funeral March piano sonata and the twenty-seven études (op. He suffered poor health for much of his life and this forced him to give up performing and teaching shortly before he died on 17th October 1849. In 1836 he met the French writer George Sand, with whom he had a relationship for nine years until 1847. In Paris, he made a career as a performer and teacher as well as a composer, and he adopted the French variant of his name, “Frédéric-François”. He never returned to Poland, but after his death his sister Ludwika took his heart to Poland - in accordance with his last will, where it was placed inside a pillar of the Holy Cross Church at Krakowskie Przedmiescie Street. There he composed his two piano concertos with their patriotic Polish themes and rhythms, based on traditional polish dances. ![]() In Warsaw he was hailed as a child prodigy and as the “second Mozart” for his piano and composition skill, for which the composer Robert Schumann complimented the talented pianist: “Hats off, gentlemen, a genius!” Due to the political situation in Poland, he left his country for France at the age of twenty. He was born Fryderyk Franciszek Chopin, of Polish and French parentage, on 1st March 1810 in the village of Żelazowa Wola, Poland. Frédéric François Chopin (1810 –1849) is one of the most famous, influential, and admired composers and virtuoso pianists of the Romantic era.
Back to Blog
3760 charmstone pion3/17/2023 ![]() Last assessment was made in 2014 and makes 203.2k. In addition, the property is equipped with a garage. Historical records for this building show one business that may no longer be listed at this address. Any services or products provided by independently owned and operated franchisees are not provided by, affiliated with or related to Sotheby’s International Realty Affiliates LLC nor any of its affiliated companies. The single-family property is situated at 3760 Charmstone Way, Carbondale, California. Each franchise is independently owned and operated. Sierra Sotheby's International Realty fully supports the principles of the Fair Housing Act and the Equal Opportunity Act. Sotheby's International Realty® and the Sotheby’s International Realty Logo are service marks licensed to Sotheby’s International Realty Affiliates LLC and used with permission. It is recommended that you hire a professional in the business of determining dimensions, such as an appraiser, architect or civil engineer, to determine such information. All dimensions are approximate and have not been verified by the selling party and cannot be verified by Sierra Sotheby's International Realty. The offerings are subject to errors, omissions, changes, including price, or withdrawal without notice. The information set forth on this site is based upon information which we consider reliable, but because it has been supplied by third parties to our franchisees (who in turn supplied it to us), we cannot represent that it is accurate or complete, and it should not be relied upon as such. Find the location and property that interests you, work with the Realtor and closing agent to learn all you can about the property, and make your offer based upon good information and research.© 2022 Sierra Sotheby’s International Realty But in order to take full advantage of these opportunities you must have all your information and take an organized approach to finding and acquiring foreclosed properties. 3 bed 2.5 bath 1,908 sqft 1.6 acre lot 3705 Charmstone Way, Ione, CA 95640 Property Type Single Family Year Built 2005 Last Sold 365K in 2017 Price per sqft 191 Share this home Edit Facts Get. Have the financing for the property in place before you enter into a firm contract with a good faith deposit, or have the contract be contingent on the financing you will need.įoreclosed properties can represent excellent opportunities to acquire real estate at bargain prices.Real estate tax liens and homeowner association liens have priority and need to be paid before clear title can be given. Have the title agent issue a title binder showing the conditions under which it will insure your interest in the title. Hire a closing attorney or title company to check the condition of the title to make certain there are no liens remaining after the foreclosure is complete. ![]() Sometimes foreclosures have title problems that have not been cleared up.Successful bidding on foreclosed properties requires discipline and good information. Never get so caught up in a property that you do not make clear decisions. Decide on how much you are willing to pay for the property and stick with that price.If the property needs repair work, have a recommended contractor give a detailed estimate of each job that must be done.Get them to give you a ballpark estimate of the property value. Through their years of familiarity with the property and the neighborhood, appraisers and real estate professionals can supply background on property and neighborhoods. Consult with a professional real estate appraiser.If foreclosure is not complete you may be able to get the information you need about the property either from the owner or the lender.While in the area scout out the neighborhood to make certain the surrounding area suits your needs. For a printable PDF copy of this guide, click here. Contact the listing broker and ask for an appointment to see it. ET-3760 Users Guide Welcome to the ET-3760 Users Guide.If foreclosure is complete, the property will be listed with a Realtor, in which case you can have an open line of communication about the property as well as the opportunity to inspect it.Plenty of outdoor space for all of your hobbies or a few farm animal friends. This property has 3 full bedrooms with a bonus room that could easily become a 4th bedroom. Steps as you search for your foreclosure property: 3760 Charmstone Way Ione, CA 95640 3 Beds 3 Baths 2,273 Sq Ft 1.09 Acres About This Home Charming country home on just over an acre.
Back to Blog
100 ml beaker3/17/2023 ![]() You most likely have one or more items in your shopping cart that are not priced. Our sales specialists know our lineup best, and are most willing to help you find the solution(s) you need! We're always adding partner brands, and it's difficult to keep up with the thousands of products that get added to our lineup. Give us a call, or drop us a line and let us know what you're looking for as best you can. We're more than happy to assist you in your search. "I'm having a hard time searching for a product." Spectra Services highly recommends that return packages be insured for full value and packaged securely to prevent shipping damage. Once completed, please return the merchandise immediately as the RMA number is only active for ten (10) days from the date of issuance.Ĭharges associated with returning items are the responsibility of the customer unless the item(s) arrived defective, damaged, or incorrect. Full credit will be issued upon receipt and inspection of the item(s) to ensure equipment was returned in the same condition it was initially shipped out in.Īll exchanges and returns require the completion of a Return Merchandise Authorization (RMA) form. No restocking fee will be assessed, however, the customer is responsible for the return shipping costs. If for some reason the customer decides to return the product, they may do so at any point during those seven (7) days for a full refund. Upon receipt of the pre-owned product(s), the customer has one week to evaluate the product to ensure it meets their expectations. Spectra Services reserves the right to review this policy on a case-by-case basis. Products with an expired shelf life or an expiration date too short for resale.Products not purchased from Spectra Services.Products which are not inventoried by Spectra Services and are not able to be returned to the manufacturer.Refrigerated products or other perishables.Labroatory apparatus or instruments that have been used or are without the original packaging, labeling and operating manuals.Chemicals, reagents, diagnostics, sterile, or any controlled products (unless products do not meet specification. ![]() Products not in completely resalable condition (including products with damaged, missing, or defaced labeling or packaging.Unfortunately, Spectra Services is unable to accept the following returns at this time: Spectra Services return authorization number (RMA).To ensure proper credit, each product return must include the following information: For returns not due to error on behalf of Spectra Services, the customer is responsible for all transportation fees related to the returned product. All returns are subject to a minimum 15% restocking charge. Globe Scientific 100mL Beaker, Three Corner, Clarified PP, Graduated, 100/BoxĪll returns must be authorized by Spectra Services in order to insure proper credit and must be requested within 30 days of purchase.C-Mount Lenses Sort Products By Number of Products to Show.Tab will move on to the next part of the site rather than go through menu items. Enter and space open menus and escape closes them as well. Up and Down arrows will open main level menus and toggle through sub tier links. Left and right arrows move across top level links and expand / close menus in sub levels. The site navigation utilizes arrow, enter, escape, and space bar key commands.
Back to Blog
6 Finally, 117 (49 men) age and sex matched (mean age 60.1 (SD 15.0) years range 35–91) asymptomatic normotensive controls were also recruited. Clinical diagnoses were based on established criteria. All patients with dementia were fully investigated using standard psychometry and neuroimaging techniques. The FTD group (in which the dementia was hypothesised to be aetiologically unrelated to CADASIL) was used as a “positive disease” control group for the AD cohort. In addition, seventy seven patients (36 men) from a specialist young dementia clinic were also recruited (mean age of disease onset 64.4 (SD 9.2) years range 46.7–89.6) comprising 55 with Alzheimer's disease (AD) with or without vascular dementia, and 22 with frontotemporal dementia (FTD). Seventy (40 men) well characterised relatively young patients with radiologically established sporadic ischaemic stroke were recruited (mean age of disease onset 68.8 (SD 13.6) years range 20–90). For these purposes, we designed an array of restriction enzymes and mismatch primers. We sought to establish a simple and reliable genetic test for the Notch3 variants clustering in exons 3 and 4, and to determine the allele frequencies of Notch3 mutations and polymorphisms in patients with stroke and dementia. Indeed, the absence of a readily accessible screening test along with the need to determine the frequency of Notch3 mutations in common related diseases masquerading as CADASIL may slow our ability to understand the pathophysiology of cerebrovascular disease. Whether mutations in such a rare monogenic syndrome account for, or have any effect on, more common phenotypes has not been investigated, partly hampered by the lack of a quick and reliable screening test. 4 5Thus, exons 3 and 4 should be screened as a first stage but, if no mutations are detected and clinical suspicion remains high the remainder of this gene should be sequenced. 3 Mutations clustering in exons 3 and 4 account for about 65% of all patients with CADASIL. 2 The disease is due to mutations in the transmembrane receptor of the Notch3 gene, which either create or destroy a cysteine residue. 1 The clinical picture is accompanied by associated magnetic imaging abnormalities. The test will enable units locally to rapidly screen patients with suspected CADASIL.Ĭerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare inherited adult onset disease characterised most commonly by cerebral ischaemic events (84%) and dementia (31%), but also migraine with aura and mood disturbances. The data suggest that despite the clinical resemblance, CADASIL is not a common masquerading cause of stroke or dementia. In conclusion, a readily usable genetic test for CADASIL has been devised that was used to determine allele frequencies in well characterised cohorts of sporadic stroke and dementia patients. Molecular variant C381T occurred with a higher frequency of 0.13, whereas G684A occurred with a lower frequency (0.09) than previously reported, although there were no statistical differences between selected cohorts. None of the 14 known mutations and three previously identified polymorphisms (C474A, A587G, and C594A) in exons 3 and 4 were present in 140 stroke, 110 dementia, or 234 control chromosomes. The diagnostic array was found to work well. One hundred and seventeen age and sex matched asymptomatic controls were also identified. Seventy patients with radiologically established sporadic ischaemic stroke and 77 patients from a specialist young dementia clinic were recruited. This array was used to identify the allele frequencies of CADASIL mutations and polymorphisms in selected disease cohorts. Whether these mutations have any influence on common sporadic ischaemic stroke or dementia cases has not been investigated, partly hampered by the lack of a readily usable genetic test.Īn easy to use diagnostic array for CADASIL was designed using various restriction endonucleases for the known mutations in exons 3 and 4 and novel mismatch primers were designed where no such enzymes existed. It is caused by mutations in the Notch3 gene with most clustering in exons 3 and 4. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare inherited adult onset disease characterised most commonly by cerebral ischaemic events and dementia.
Back to Blog
Radiologik dj not autoscheduling3/16/2023 ![]() Radiologik Scheduler runs the appropriate script 20 minutes before the start time and sends that set of tracks and directions to Radiologik DJ's program queue. Time announcement files are dynamically selected by Radiologik DJ to always be the correct time. You can use many smart playlists for the same segment, giving you the ability to set when to play fast, medium, or slow songs or how often to play tired songs versus new songs that you may want to play more often. It schedules to DJ's program queue using iTunes/Music playlists to allow a 24/7 fully-automated station. This can give you a reservoir of tracks that have not played recently but enough tracks to still pick at random, effectively giving a random rotation. Radiologik Scheduler is the companion application to Radiologik DJ. Pete Stover is general manager of WWED (FM)/WWEM (FM). Because Radilogik DJ tells iTunes when it plays a track, you can use smart playlists to be sure you are not playing certain songs again for a specified period of time. Having used broadcast automation systems and software since 1983, we have found Radiologik DJ and Scheduler to be the best choice by far. ![]() Playlists, and particularly smart playlists in iTunes, give programming tracks enormous power. The resolution of the script statements are in seconds. It builds these segments in 30 or 60 minute blocks anywhere inside of a week schedule. Radiologik Scheduler chooses tracks from playlists in iTunes with a little bit of extra logic to figure out times and artist separation. New in 2018: Setup of audio devices is easier now without the need. It is a free complement to Radiologik DJ. Shows how to setup the D&R Airlite radio console for audio and control with Radiologik DJ. This release of the Scheduler component of Radiologik is a public development build of the features of Radiologik Scheduler Basic. It is a free complement to Radiologik DJ. |